What is Protein Sequence?

A protein sequence refers to the specific order in which amino acids are arranged in a protein chain. Each protein has a characteristic number and sequence of amino acid residues. The primary structure of a protein determines how the protein folds into a unique three-dimensional structure secondary, tertiary, and quaternary structures, which in turn determines the biological function of the protein. Protein sequences are critical for exploring mechanisms of diseases, designing therapeutic interventions, and advancing biotechnological applications.

The determination of protein sequence information can be used to design oligonucleotide probes complementary to the predicted gene sequence. These nucleic acid probes play an important role in cloning new genes encoding low-abundance proteins. For example, genes encoding many important drug proteins used in the clinic. Protein sequencing analysis can directly identify post-translational modifications that cannot be predicted from gene sequences, characterize recombinant proteins, and fragments of natural and recombinant proteins for structural and functional studies. Recombinant protein drugs can also be characterized to ensure that the expressed product conforms to the predicted structure, and to evaluate the quality and purity of the product to be highly consistent.

Creative Proteomics is a reliable partner of biopharmaceuticals. We provide reliable, high-quality protein sequence analysis service in accordance with relevant guidelines (ICH Q6B and USP<1047>) and perfect pre-sales and after-sales services.

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Why Choose Our Protein Sequencing Service 

• Rich Experience: Our company has been engaged in protein analysis of biopharmaceuticals for 16 years.

• Professional Platforms: High-resolution (greater than 105), high-quality accuracy (less than 1ppm) mass spectrometry platform and reverse phase high performance liquid chromatography (RP-HPLC) to ensure the accuracy of identification results.

• Bioinformatics Services: Our bioinformatics analysts can help you interpret the final data.

• Customized Service: You can choose the appropriate test item according to your project, and we will customize a unique solution for you.

Creative Proteomics' analytical scientists can provide quick turnover, clear and concise written reports and customized services to help customers solve analytical and technical problems.

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Applications of Protein Sequencing

• Biomarker Discovery and Disease Research: Protein sequencing is instrumental in identifying novel biomarkers for disease detection and therapy monitoring.

• Therapeutic Protein Development: In the pharmaceutical industry, protein sequencing ensures the correct structure and functionality of therapeutic proteins. It is also critical in the development of biosimilars and in ensuring regulatory compliance for biologic drugs.

• Proteomics and Structural Biology: Protein sequencing plays a central role in structural proteomics, enabling the determination of 3D protein structures and interaction networks.

• Post-Translational Modification Analysis: Protein sequencing enables the detection and mapping of PTMs, which are essential for understanding protein function, stability, and interactions in cellular processes.

• Protein Engineering: By providing insights into protein sequences, protein sequencing aids in the engineering of novel proteins for various industrial applications, including enzyme design, antibody development, and therapeutic proteins.