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Precision Quantitative Proteomics Services for Discovery & Translation

Creative Proteomics offers a robust portfolio of quantitative proteomics solutions (RUO), powered by standardized LC–MS/MS workflows and traceable reporting. We specialize in transforming complex biological samples into reproducible datasets for discovery, verification, and high-throughput translational research.

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Cutting-Edge Quantification Technologies

To support cohort-scale studies where data completeness is paramount, we provide industry-leading 4D-DIA (dia-PASEF®) and DIA platforms, ensuring unrivaled sensitivity and throughput.

  • Discovery Proteomics (Untargeted):

    • Label-based: TMT (up to 18-plex), iTRAQ, and SILAC for precise relative quantification.

    • Label-free: LFQ and DIA (Data-Independent Acquisition) for deep proteome coverage.

    • 4D-Technology: 4D-DIA leveraging TIMS/CCS for increased dynamic range.

  • Targeted Proteomics (Verification):

    • Absolute Quantification: AQUA, PRM (Parallel Reaction Monitoring).

    • Gold Standard: SRM/MRM for validated biomarker screening.

  • Customized Services: Semi-quantitative analysis tailored to specific project requirements.

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Why MS-Based Protein Quantification?

Thanks to the enhanced sensitivity, resolution, and mass accuracy of MS, along with innovations in high-performance liquid chromatography (HPLC), computational power, and software development, researchers can now achieve precise quantification of individual proteins and entire proteomes.

MS-based quantification enables highly accurate and reproducible analysis of protein abundance and post-translational modifications (PTMs) across different biological conditions (e.g., healthy vs. diseased states). These insights help:

  • Decipher molecular interactions and signaling pathways

  • Identify disease mechanisms at the phenotypic level

  • Discover biomarkers for improved diagnostics, prognosis, and therapeutic interventions

Consequently, quantitative proteomics has become an integral part of modern biological and pharmaceutical research.

​

Cutting-Edge Quantification Technologies

To support cohort-scale studies where data completeness is paramount, we provide industry-leading 4D-DIA (dia-PASEF®) and DIA platforms, ensuring unrivaled sensitivity and throughput.

  • Discovery Proteomics (Untargeted):

    • Label-based: TMT (up to 18-plex), iTRAQ, and SILAC for precise relative quantification.

    • Label-free: LFQ and DIA (Data-Independent Acquisition) for deep proteome coverage.

    • 4D-Technology: 4D-DIA leveraging TIMS/CCS for increased dynamic range.

  • Targeted Proteomics (Verification):

    • Absolute Quantification: AQUA, PRM (Parallel Reaction Monitoring).

    • Gold Standard: SRM/MRM for validated biomarker screening.

  • Customized Services: Semi-quantitative analysis tailored to specific project requirements.

​

Why MS-Based Protein Quantification?

Thanks to the enhanced sensitivity, resolution, and mass accuracy of MS, along with innovations in high-performance liquid chromatography (HPLC), computational power, and software development, researchers can now achieve precise quantification of individual proteins and entire proteomes.

MS-based quantification enables highly accurate and reproducible analysis of protein abundance and post-translational modifications (PTMs) across different biological conditions (e.g., healthy vs. diseased states). These insights help:

  • Decipher molecular interactions and signaling pathways

  • Identify disease mechanisms at the phenotypic level

  • Discover biomarkers for improved diagnostics, prognosis, and therapeutic interventions

Consequently, quantitative proteomics has become an integral part of modern biological and pharmaceutical research.

 

Our Advanced Protein Quantification Services

With extensive experience in proteomics research, Creative Proteomics offers a range of cutting-edge quantitative proteomics solutions, including:

1) iTRAQ proteomics analysis service

2) TMT proteomics analysis service

3) SILAC proteomics analysis service

4) Absolute quantification (AQUA) service

5) Label-free quantification service

6) Semi-quantitative proteomics analysis service

7) Parallel Reaction Monitoring (PRM)

8) SRM&MRM

9) DIA Quantitative Proteomics Service

10) 4D-DIA Quantitative Proteomics Service

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