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What is Spatial PTM Mapping?

Post-translational modifications (PTMs) are the "on/off" switches of cellular function. While genomics tells you the blueprint and proteomics tells you the machinery, PTM mapping tells you the activity.

Spatial PTM Mapping utilizes advanced technologies—such as MALDI-MSI (Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging) or Antibody-based Multiplexing—to detect specific chemical changes on proteins across a 2D or 3D tissue landscape. This allows for the visualization of localized signaling pathways within tumors, brain regions, or inflamed tissues.

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Our Technology Platform

We utilize a multi-modal approach to suit diverse research needs:

  • MALDI-TOF/TOF & FT-ICR MSI: For label-free, discovery-based mapping of glycans and small molecule modifications with high mass accuracy.

  • High-Plex Spatial Proteomics: Using DNA-barcoded antibodies to detect dozens of specific phosphorylated proteins simultaneously at sub-cellular resolution.

  • Advanced Image Fusion: Proprietary software to overlay molecular heatmaps onto high-resolution histological images.

Key Applications

  • Oncology: Identifying "active" signaling zones in the tumor microenvironment to predict drug resistance.

  • Neuroscience: Mapping protein phosphorylation patterns in neurodegenerative diseases like Alzheimer's or Parkinson's.

  • Drug Development: Visualizing the spatial distribution of a drug's effect on target protein modification (Pharmacodynamics).

  • Immunology: Tracking the activation state of immune cells as they infiltrate specific tissue niches.

Why Choose Us?

  • Unmatched Sensitivity: Our platform detects low-abundance PTMs that are often missed by standard imaging techniques.

  • Expert Integration: We don't just provide raw data; we provide biological context, linking molecular shifts to morphological features.

  • Customization: We develop bespoke protocols for "difficult" modifications or unique tissue types.

  • Validated Accuracy: Every project includes rigorous internal standards to ensure spatial and chemical fidelity.

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